Journal Article Biocompatible Materials Calcium Compounds EC 2.7.10.1 EC 3.4.24.24 Heterotopic ossification Hydrogels Inflammasomes Kdr protein, rat Macrophages Matrix Metalloproteinase 2 NLR Family, Pyrin Domain-Containing 3 Protein Nlrp3 protein, mouse Nucleotide-binding and oligomerization domain-like receptor 3 (NLRP3) Pyroptosis Research Support, Non-U.S. Gov't S4255P4G5M Silicates Silk Stimulator of interferon genes (STING) angiogenesis bioelectronic implant calcium silicate chirality hydrogels macrophages nerve modulation responsive-gene-silencing properties self-healing hydrogels silk material